This new product would have the unique advantage of both being able to prevent cataracts before they start or to treat cataracts after they form, she said. The 5-year probability of progression to cataract surgery in the no lutein/zeaxanthin group was 24%. Delcourt C, Carrire I, Delage M, Barberger-Gateau P, Schalch W; POLA Study Group. The effect of Centrum use on our results cannot be determined because nearly all participants took the supplement. The severity and progression of cortical and PSC opacities on the red reflex lens photographs and the presence of pseudophakia or aphakia were graded at the reading center. None of the nutrients studied affected rates of moderate or worse vision loss, defined as a loss of 15 or more letters from baseline. Chew EY, Clemons T, SanGiovanni JP, et al. Photo by Olivia McClure/LSU AgCenter, The LSU AgCenter and the LSU College of Agriculture, 101 Efferson Hall The absence of an effect of the interventions on the rates of cataract surgery may indicate an absence of an effect on nuclear and/or PSC opacities, which are the subtypes most likely to affect vision and by far the most common causes of the need for cataract surgery.3436 Nuclear and PSC opacities have been reported in 65% and 61% of surgical cases, respectively.36 Cortical opacities alone are an uncommon cause of cataract surgery. A test of interaction between treatment and the quintile groups had a P value of .003. Lutein and zeaxanthin and the risk of cataract: the Melbourne Visual Impairment Project, A prospective study of carotenoid intake and risk of cataract extraction in US men. JAMA Ophthalmol. The study examined the effects of lutein/zeaxanthin on progression to cataract surgery with data collected during regular telephone contacts and the annual study visits. To determine whether daily oral supplementation with lutein/zeaxanthin affects the risk for cataract surgery. For lutein/zeaxanthin vs no lutein/zeaxanthin, the hazard ratios for progression to cataract surgery was 0.96 (95% CI, 0.841.10; P = .54). Interpreting the cataract findings, particularly those for lutein/zeaxanthin, requires consideration of the AREDS2 study design and study population. Details of the AREDS2 study design described in a previous report25 are briefly summarized here. Conflict of Interest Disclosures: None reported. Whether supplementation would be beneficial for less well-nourished populations requires further study. Serum levels of the study nutrients were balanced across treatment groups at baseline. The prevalence of age-related cataract is increasing, with an estimated 30.1 million Americans likely to be affected by 2020. The possible effect of competitive absorption of carotenoids, which has been demonstrated in other human studies31,32 and in animal studies,33 also needs consideration. The study population had a mean (SD) age of 72 (7.7) years. Additional analyses and subgroup analyses were analyzed in the same fashion as the primary lens efficacy outcome. 2002 global update of available data on visual impairment: a compilation of population-based prevalence studies. A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation for age-related lens opacities: clinical trial of nutritional supplements and age-related cataract report no. Approximately 80% of the participants took the study medications at least 75% of the time, as assessed by pill count. The use of vitamin supplements and the risk of cataract among US male physicians, Antioxidant vitamins and nuclear opacities: the longitudinal study of cataract. In the absence of any consensus about the importance of specific micronutrients, several controlled clinical trials have tested whether selected micronutrients with antioxidant characteristics or multivitamins affect cataract development.1117 Because of variable results, no clear treatment recommendation has resulted from the trials conducted to date. Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Kuzniarz M, Mitchell P, Cumming RG, Flood VM. Recruitment of participants was based on retinal findings of bilateral large drusen or large drusen in 1 eye and advanced AMD in the fellow eye. 225-578-4143 Of this group, 2264 participants (72%) agreed to the secondary randomization evaluating modifications to the AREDS supplements. The median follow-up duration was 4.7 years (inter-quartile range, 4.45.1 years). Dietary lutein/zeaxanthin, g/d/1000 kcal. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. Bilateral pseudophakia was present in 1044 participants who were excluded from the cataract analyses, leaving 6027 study eyes (3159 participants). New formulations may prove more reliable and effective. There was also no specific eligibility criterion for visual acuity. Dietary modulation of lens zeaxanthin in quail, Measurement of carotenoids, retinoids, and tocopherols in human lenses. Is it of any value? Seddon JM, Christen WG, Manson JE, et al. Once cataracts form, they tend to grow, clouding larger and larger areas of the lens. At that time, 42% already had some cortical opacities and 8% had some PSC opacities. They could not have other ocular diseases that might confound assessment of the ocular outcomes or other systemic diseases including lung cancer or other diseases associated with poor 5-year survival. Bethesda, MD 20894, Web Policies Clinical trial results for the AMD component of AREDS2 are presented elsewhere. All rights reserved. A comparison of lutein/zeaxanthin to no lutein/zeaxanthin for progression to cataract surgery resulted in a HR of 0.96 (95% CI, 0.841.10; P = .54) (Figure 3). Botox for Blepharospasm the Blinking Disorder? out of DrWeil.com subscriptions at any time. An official website of the United States government. The study medications and raw materials were provided by Alcon, Bausch and Lomb, DSM, and Pfizer. web@agcenter.lsu.edu, 106 Martin D. Woodin Hall Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Traditional treatment involves surgical removal of cataracts from the eye lens. However, a previous randomized clinical trial17 and observational data from AREDS29,30 suggested that use of multi-vitamins, such as Centrum, might retard cataract development. The new PMC design is here! Age-Related Eye Disease Study Research Group. Cataracts usually are age-related and represent accumulated free-radical damage to the protein molecules that form the lens of the eye. Glasses Why do I need glasses after cataract surgery? Dr. Weil's FREE health living advice delivered to you! Terms and Conditions For this outcome, the comparison of lutein/zeaxanthin vs no lutein/zeaxanthin yielded a HR of 0.93 (95% CI, 0.831.04; P = .20) (Figure 3). The procedure is very safe, effective, and quick. Annual best-corrected visual acuity testing was performed. Vitamin supplement use and incident cataracts in a population-based study. Given the advanced age of participants, cataracts may have already begun to develop in many who had no apparent opacities at the start of the study. HHS Vulnerability Disclosure, Help Participants and study personnel were masked to all treatment assignments. Fruit, Herb, & Vegetable Infused Waters: Good Or Bad? The primary cataract outcome in AREDS2 was cataract surgery, with the secondary outcomes of progression of lens opacities or change in visual acuity. Other outcomes included (1) progression to cataract surgery or an absolute increase in opacity size (area) within the central 5 mm of the lens or 10% for cortical or 5% for PSC opacities; (2) progression to cataract surgery or a 20% absolute increase in the area of either opacity within the central 5 mm of the lens; and (3) a reduction in visual acuity of 15 or more letters from baseline. National Eye Institute/National Institutes of Health, Bethesda, Maryland (Chew, SanGiovanni, Ferris, Wong, Agron); EMMES Corp, Rockville, Maryland (Clemons, Sperduto); University of Wisconsin, Madison, Wisconsin (Danis, Chandra, Blodi, Domalpally); Elman Retina Group PA, Baltimore, Maryland (Elman); Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, North Carolina (Antoszyk); Vision Research Foundation, Royal Oak, Michigan (Ruby); Ingalls Memorial Hospital, Harvey, Illinois (Orth); Retina Division at Wilmer Eye Institute, Baltimore, Maryland (Bressler); Texas Retina Associates, Dallas, Texas (Fish); Emory University Eye Center, Atlanta, Georgia (Hubbard); Devers Eye Institute, Portland, Oregon (Klein); University of Pittsburgh Medical Center Eye Center, Pittsburgh, Pennsylvania (Friberg); Bascom Palmer Eye Institute, Miami, Florida (Rosenfeld); Duke University, Durham, North Carolina (Toth); University of Utah (Moran Eye Center), Salt Lake City, Utah (Bernstein). Strengths of the study include 5-year follow-up, low losses to follow-up, standardized data collection, and good compliance with the treatment regimen. The primary outcome, cataract surgery, is a clinically important and an easily verified outcome. Serum levels of lipids, lutein/zeaxanthin, fat soluble vitamins, zinc, and copper were measured at baseline and years 1, 3, and 5 in 545 participants from a subset of clinics. NAC is available in this country, but no claims can be made for its effectiveness, so it is listed as an inactive ingredient. Median baseline serum levels of lutein in participants randomized to lutein increased by 191% to 215% at years 1, 3, and 5, while those randomized to placebo showed minimal changes. Duplicate gradings of the red reflex lens photographs demonstrated 93% agreement for the presence of cortical opacities and 97% agreement for the presence of PSC. Indeed, evidence suggests that a regular and healthy intake of both lutein and zeaxanthin in a persons diet can help protect the eyes against cataracts, macular degeneration and other ocular conditions. HHS-N-2602005-00007-C and ADB contract No. Find out about all the signs and appearance of cataracts. Results for quintiles 2 through 4, also displayed in Figure 4, were greater than quintile 1 and less than quintile 5. For the same outcome, in subgroup analyses by quintiles of lutein/zeaxanthin intake, a comparison of lutein/zeaxanthin vs no lutein/zeaxanthin resulted in HRs of 0.64 (95% CI, 0.460.89; P = .008) and 1.26 (95% CI, 0.911.75; P = .17) for the lowest and highest quintiles of dietary lutein/zeaxanthin, respectively. Components of the AREDS2 formulation, donated by DSM Nutritional Products, include lutein/zeaxanthin supplied as water soluble triglyceride compounds and omega-3 LCPUFA formulation supplied in ethyl ester form as Ropufa 75 n-33 EE. Some participants received both beta carotene and lutein/zeaxanthin, while others received lutein/zeaxanthin alone. Found in leafy green vegetables like spinach, kale and collard greens, both lutein and zeaxanthin are carotenoid antioxidants that have been linked to reducing the risk(1), or, postponing the onset, of eye conditions such as cataracts. AREDS reported that use of oral supplements containing vitamin C, vitamin E, and beta carotene, as well as the minerals zinc and copper, did not affect the progression of lens opacities.18 In AREDS2, we found neither beneficial nor harmful effects on the rates of cataract surgery or moderate vision loss when lutein/zeaxanthin was added to the AREDS formulation. For lutein/zeaxanthin vs no lutein/zeaxanthin, the HR for progression to severe cataract was 0.94 (95% CI, 0.831.07; P = .33). These nutrients were considered only important for the treatment of AMD but they need to be considered for potential interaction with the primary randomization. Telephone contacts were scheduled 3 months after randomization and at 6 months between study visits to collect information about compliance with study medication, AMD treatment, cataract surgery, and occurrence of adverse events. AREDS2 was designed to test large doses of lutein/zeaxanthin, 10mg/2mg, against near dietary levels of intake. The photographs were assessed by masked graders for the severity of cortical and posterior subcapsular cataract (PSC) lens opacities at the University of Wisconsin Fundus Photograph Reading Center, Madison, Wisconsin. Abbreviations: AREDS2, Age-Related Eye Disease Study 2; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; IQR, interquartile range. Teikari JM, Virtamo J, Rautalahti M, Palmgren J, Liesto K, Heinonen OP. But treatments using lutein have been limited in the past by the substances poor water solubility, its susceptibility to degradation and low absorption efficiency. The unit of analysis for ophthalmic outcomes was by eye. 3. sharing sensitive information, make sure youre on a federal Find services and support for cataract patients. official website and that any information you provide is encrypted Jacques PF, Chylack LT Jr, Hankinson SE, et al. Study participants were randomly assigned to take 1 of the following supplements daily: (1) placebo; (2) lutein/zeaxanthin; (3) DHA/EPA; or (4) lutein/zeaxanthin and DHA/EPA. Lutein can also be found in the human eye. Long-term supplementation with alpha-tocopherol and beta-carotene and age-related cataract, A randomized trial of beta carotene and age-related cataract in US physicians, The Linxian cataract studies: two nutrition intervention trials. In addition, make sure that your diet includes foods that are rich in the antioxidants lutein and zeaxanthin, carotenoids that can help promote eye health. (04/28/16) BATON ROUGE, La. A study ophthalmologist examined the anterior segment using slitlamp biomicroscopy at the annual visit to diagnose or confirm the presence of pseudophakia or aphakia. Copyright2022 Healthy Lifestyle Brands, LLC. AREDS2 participants in the lowest quintile of dietary intake of lutein/zeaxanthin showed some evidence of a beneficial effect of lutein/zeaxanthin supplementation on the progression to the cataract outcomes. ; CAREDS Study Group; Womens Health Initiative. The nanoparticle matrix can deliver lutein to the eye efficiently as an eye drop formulation, Sabliov said. 2022 content kindly provided by SpaMedica. Lutein is a naturally occurring yellow pigment known as a carotenoid. A cataract is a clouding of the lens in the eye that blurs vision, changes the way you see colors (they seem faded) and generally reduces visual acuity. Milton RC, Sperduto RD, Clemons TE, Ferris FL III; Age-Related Eye Disease Study Research Group. AREDS2 enrolled 4203 people with a mean (SD) age of 73.1 (7.7) years. For participants in the lowest quintile of dietary intake of lutein/zeaxanthin, the hazard ratio comparing lutein/zeaxanthin vs no lutein/zeaxanthin for progression to cataract surgery was 0.68 (95% CI, 0.480.96; P = .03). Group Information: The AREDS2 Research Group is found online in the Supplement (eAppendix). At baseline, 2878 participants were bilaterally phakic, while 281were pseudophakicin1 eye. No clinically or statistically significant serious adverse effect was associated with the treatments. Baseline Characteristics of Participants Enrolled in AREDS2 Cataract Study. A large percentage of participants (89%) requested Centrum Silver at study entry. www.drweil.com. You can get sulfur from onions, garlic, shallots and capers and can boost your intake with supplements of alpha-lipoic acid (ALA) (250 mg twice a day) and N-acetylcysteine (600 mg twice a day). Perhaps the intervention was too late or of insufficient duration to affect the outcomes. 21, Carotenoid bioavailability and bioconversion, Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. Certified photographers obtained red reflex lens photographs at baseline and annually. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1), Underwood Memorial Lecture: human zinc homeostasis: good but not perfect, Regression analysis of multivariate incomplete failure time data by modeling marginal distributions. The hazard ratio for 3 or more lines of vision loss was 1.03 (95% CI, 0.931.13; P = .61 for lutein/zeaxanthin vs no lutein/zeaxanthin). The antioxidant glutathione can also help, but it doesnt come directly from foods the liver manufacturers it after you consume sulfur or certain amino acids. Privacy Policy. Of the randomized participants, 96% were white and 55% were female. Best-corrected visual acuity was obtained annually using a standardized protocol. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an ancillary study of the Womens Health Initiative. It seems to work well in dogs, but according to Robert Abel Jr., M.D., a Delaware-based ophthalmologist and author of The Eye Care Revolution, (Kensington, 2004) the results of human studies to date have been variable and unpredictable. LSU AgCenter scientists have formulated a nanoparticle matrix that could be used in eye drops to both prevent and treat cataracts, a leading cause of vision loss in older adults. About 3% of participants began taking lutein/zeaxanthin in both treatment arms; approximately 19% of these participants stopped their study medications permanently. Cataracts are a common condition in older adults that causes the lens of the eye to become cloudy and block light from the retina. Resnikoff S, Pascolini D, Etyaale D, et al. Oral supplementation daily with lutein/zeaxanthin, DHA/EPA, or the modifications of the AREDS formulation had no effect on mortality. Surgery How is a cataract operation performed? 2013 Jul; 131(7): 843850. Prevalence of cataract and pseudophakia/aphakia among adults in the United States, The Lens Opacities Case-Control Study: risk factors for cataract. The lens efficacy outcome, the time to progression to cataract surgery, was assessed with a Cox proportional hazards model using the Wei, Lin, and Weissfeld method for obtaining robust variance estimates, allowing for dependence among multiple event times (1 or 2 study eyes).27 The models were run with and without stratification by the secondary randomization. Funds were contributed to these contracts by the following National Institutes of Health institutes: Office of Dietary Supplements; National Center for Complementary and Alternative Medicine; National Institute on Aging; National Heart, Lung and Blood Institute; and National Institute of Neurological Disorders and Stroke. Eat leafy, green vegetables every day, and take a well-balanced vitamin supplement that contains a variety of antioxidants and nutrients. Institutional review boards at the clinical sites approved the AREDS2 research protocol, and participants provided written informed consent. Send us an email with your question and we will get back to you within 48hrs. A test of interaction between treatment and the quintile groups showed a P value of .006. Maraini G, Williams SL, Sperduto RD, et al. The lutein eye drops could offer an effective, non-surgical and more accessible treatment option. Supplements are available for eye health that provide optimum amounts of lutein and other key antioxidant vitamins and minerals. An additional consideration in interpreting the results is the timing and duration of the use of the supplements. Follow-up study visits were conducted annually. The number of eyes and Kaplan-Meier probabilities (N[%]) of progression to cataract surgery by 5 years for study eyes randomized to lutein/zeaxanthin or no lutein/zeaxanthin were 681 eyes (24%) and 708 eyes (24%), respectively (Figure 2). Before This includes the Age-Related Eye Disease Study (AREDS), which tested a formulation containing vitamin C, 500 mg; vitamin E, 400 IU; and beta carotene, 15 mg; as well as the minerals zinc (as zinc oxide), 80 mg, and copper (as cupric oxide), 2 mg, for both age-related macular degeneration (AMD) and cataract.18 Although AREDS showed a 25% beneficial effect for reducing the risk for developing advanced AMD, it showed no statistically significant effect of the AREDS formulation on the progression of lens opacities. In addition to lutein and zeaxanthin, vitamins C and E, glutathione, polyphenols, omega-3, manganese and zinc have all been linked to improved eye health, as well. About half of the AREDS2 cohort who consented to the secondary study randomization were assigned to take high doses of beta carotene and the other half to no beta carotene. This article evaluates the role of lutein/zeaxanthin for the treatment of age-related lens opacities, specifically for progression to cataract surgery. Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR. There is significant scientific evidence that suggests(1) that lutein helps to stave off cataracts. Christen W, Glynn R, Sperduto R, Chew E, Buring J. Age-related cataract in a randomized trial of beta-carotene in women, The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India. Its widely agreed upon, though, that these two carotenoids are not the entire picture when it comes to vitamins and minerals that promote eye health, as they work in concert with various other antioxidants and carotenoids to prevent oxidative stress in the eye and help to prevent the damage caused when blue light hits the macula. 225-578-4161 The .gov means its official. significant scientific evidence that suggests, Lutein and zeaxanthin function as blue light filters, and, as such, can help reduce the risk of cataracts, American Optometric Association (AOA): Diet and nutrition, All About Vision: Lutein and zeaxanthin: Eye and vision benefits. It can be found in numerous plants, including yellow flowers and corn, as well as egg yolks and animal fats. Baseline dietary intake of the study nutrients, excluding the supplements, such as Centrum Silver, was balanced across treatment groups. A test of interaction between treatment and the quintile groups showed a P value of .01. Subgroup analyses restricted to quintiles of dietary lutein/zeaxanthin in-take resulted in nonstatistically significant HRs from the first through fifth quintiles (data not shown). *AREDS2 Research Group Writing Team: The members of the writing team and their affiliations are found at the end of this article. A second randomization was conducted for the AMD component of the trial. Assessing nuclear opacities requires specialized slit-lamp photography, which was not readily available in a retinal practice, so that information on nuclear cataract was incomplete. Safety outcomes included mortality. The reduction in the serum levels of lutein/zeaxanthin in those participants who received both carotenoids may be the result of the apparent systemic competitive absorption of carotenoids. You also agree to receive emails from DrWeil.com, and you may opt Long-term nutrient intake and early age-related nuclear lens opacities. Tips and advice on ensuring the success of your treatment. At base-line, 1239 of 2943 participants (42%) had cortical cataract and 229 of 2941 (8%) had PSC cataract. Participants were eligible for enrollment at their randomization visit if they took at least 75% of the run-in medications and if they agreed to take the AREDS2 supplements and stop current use of supplements containing lutein, zeaxanthin, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), vitamin C, vitamin E, beta carotene, zinc, or copper, unless supplied by AREDS2. Federal government websites often end in .gov or .mil. The Centrum Silver (Pfizer Inc) was offered to all study participants to standardize multivitamin intake. Distributions were similar across the 4 treatment groups. Studies have shown that dietary supplements can help replenish ocular lutein. Eighty-two retinal specialty clinics enrolled 4203 participants, aged 50 to 85 years, from October 2006 through September 2008. No statistically significant effect was noted for any or severe cataract, defined as cataract surgery or specific levels of progression of cortical or PSC opacities. The primary outcome of the cataract clinical trial was progression to cataract surgery. At least 1 eye of each participant was free of advanced AMD. ; Clinical Trial of Nutritional Supplements and Age-Related Cataract Study Group. N-acetylcarnosine (NAC) eye drops are used in Europe to slow or reverse formation of cataracts. Baseline characteristics were comparable across the 4 treatment groups in the primary randomization (Table). The Age-Related Eye Disease Study 2 (AREDS2), a multicenter, double-masked clinical trial, enrolled 4203 participants, aged 50 to 85 years, at risk for progression to advanced age-related macular degeneration. or Healthy Lifestyle Brands. Professor Cristina Sabliov and assistant professor Carlos Astete in the AgCenter Department of Biological and Agricultural Engineering have found a way to use nanoparticles to efficiently deliver hydrophobic lutein and enhance its stability and antioxidant properties so it can be used effectively in eye drops. Masked duplicate photographic gradings were conducted every month on 5% of eyes randomly selected from the previous months evaluations, resulting in 1293 eyes that had repeat gradings between 2009 and 2012. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study, The use of a self-administered questionnaire to assess diet four years in the past. All analyses were conducted following the intention-to-treat principle and using SAS software version 9.2 (SAS Institute Inc). Learn more The nanoparticle matrix may enhance the benefits of lutein by preventing it from disintegrating before it collects in the eye lens, where cataracts occur, Sabliov said. The HR for lutein/zeaxanthin vs no lutein/zeaxanthin for mortality was 0.92 (95% CI, 0.701.21; P = .54). McNeil JJ, Robman L, Tikellis G, Sinclair MI, McCarty CA, Taylor HR. AREDS2 was conducted at 82 retinal specialty clinics and the primary focus was on the retinal outcomes. Comparison of omega-3 LCPUFAs vs no omega-3 LCPUFAs resulted in a nonstatistically significant HR of 1.01 (95% CI, 0.881.15; P = .93). Direct application of lutein to the eye in this formulation improves its effect against cataracts.. There were more than 24 million cases of cataracts in the U.S. in 2010, according to the National Eye Institute. Subgroup analyses restricted to quintiles of dietary lutein/zeaxanthin intake resulted in HRs for the first and fifth quintiles of 0.68 (95% CI, 0.480.96; P = .03) and 1.27 (95% CI, 0.911.79; P = .16), respectively (Figure 4). AREDS2 volunteers were generally better educated and better nourished than the general population, with higher dietary intake levels of lutein/zeaxanthin and omega-3 LCPUFAs. A run-in phase using study placebo and the AREDS formulation tested the participants likely ability to adhere to the study regimen. Vitamin E supplementation and cataract: randomized controlled trial. You should not use the information on this website for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment. Causes and prevalence of visual impairment among adults in the United States. The mean age of AREDS2 participants at enrollment into the follow-up study was 72 years. The AREDS2 randomized clinical trial was designed to evaluate whether oral supplementation with lutein/zeaxanthin and/or omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) might affect development of advanced AMD. You may be able to avoid cataracts or slow their growth by not smoking, wearing UV protective sunglasses and keeping your blood sugar under control (type 2 diabetes is a leading cause of vision loss). Progression to Cataract Surgery in Age-Related Eye Disease Study 2 Participants by Treatment (Lutein/Zeaxanthin vs No Lutein/Zeaxanthin), Effect of Lutein/Zeaxanthin Supplementation on the Progression of Cataract Stratified by Dietary Intake of Lutein/Zeaxanthin, Effect of Lutein/Zeaxanthin Supplementation on Moderate Vision Loss (3 or More Lines) From Baseline Stratified by Dietary Intake of Lutein/Zeaxanthin. A second consideration is that a large proportion of AREDS2 participants (89%) elected to take Centrum Silver supplements, which contain a small amount of lutein, 250 g, along with other carotenes and other antioxidants that may affect cataract development.
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